The number to aim for when talking about Defense is 490. At 490 Defense, you can (almost) no longer be 'crit' by any mob/boss up to three levels higher than you, which will cover all heroics and raid mobs and bosses.
Generally, you have 350 Defense out of the box, and 20 Defense skill from the Anticipation talent (for both Warrior and Pally Prot trees) so that means you need +120 Defense from gear, which translates to 285 Defense Rating.
If you add up all gear from the list for warrior, you will have 308 Defense Rating, which is an 'overkill'. Of course, this doesn't take into account enchantments and gems. So, it's something to keep in mind to balance out together with the enchants.
The following are enchants that will go on (and can safely be counted towards the 285 required) mainly because there is nothing better to go on that slot.
Head: Glyph of the Defender [+16 Defense Rating, +17 Dodge Rating] (Requires Keepers of Time - Revered)
Shoulder: Greater Inscription of Warding [+15 Dodge Rating, +10 Defense Rating] (Requires Aldor - Exalted)
So, the final number? 258 Defense Rating. Which means we'll have a fair amount of leeway to play with in terms of gear to get more Stamina and Avoidance.
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